Subproteome analysis of the neutrophil cytoskeleton.

  title={Subproteome analysis of the neutrophil cytoskeleton.},
  author={Ping Xu and Mark S. Crawford and Michael Way and Jasminka Godovac-Zimmermann and Anthony W Segal and Marko Radulovic},
  volume={9 7},
Neutrophils play a key role in the early host-defense mechanisms due to their capacity to migrate into inflamed tissues and phagocytose microorganisms. The cytoskeleton has an essential role in these neutrophil functions, however, its composition is still poorly understood. We separately analyzed different cytoskeletal compartments: cytosolic skeleton, phagosome membrane skeleton, and plasma membrane skeleton. Using a proteomic approach, 138 nonredundant proteins were identified. Proteins not… CONTINUE READING


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