Subpopulations of rat vascular smooth muscle cells as discriminated by calcium release mechanisms from internal stores.

@article{Shin1991SubpopulationsOR,
  title={Subpopulations of rat vascular smooth muscle cells as discriminated by calcium release mechanisms from internal stores.},
  author={Wee Soo Shin and Teruhiko Toyo-Oka and Masatoshi Masuo and Yasuji Okai and Haruyasu Fujita and T Sugimoto},
  journal={Circulation research},
  year={1991},
  volume={69 2},
  pages={
          551-6
        }
}
Transsarcolemmal influx and release from the sarcoplasmic reticulum (SR) through specific Ca2+ channels are the two main pathways to elevate cytosolic Ca2+ (Ca2+i) in vascular smooth muscle cells (VSMCs). To elucidate intercellular distribution and function of the Ca2+ channel in SR in cultured VSMCs, we observed Ca2+i transients by digital two-dimensional imaging with a fluorescent Ca2+ indicator, fura-2, and found an alternative response to either caffeine or angiotensin II under the… CONTINUE READING

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