Subordination stress alters alternative splicing of the Slo gene in tree shrew adrenals.

Abstract

It was previously hypothesized that stress hormones regulate the alternative splicing of Slo potassium channels, thereby tuning the intrinsic excitability of adrenal chromaffin cells. Male tree shrews subjected to chronic stress by exposure to a dominant male develop robust symptoms with parallels to human depression. We report here that adrenals from males… (More)

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