Suboptimal engagement of the T-cell receptor by a variety of peptide-MHC ligands triggers T-cell anergy.

@article{SadeghNasseri2010SuboptimalEO,
  title={Suboptimal engagement of the T-cell receptor by a variety of peptide-MHC ligands triggers T-cell anergy.},
  author={Scheherazade Sadegh-Nasseri and Sarat Kumar Dalai and Laura C Korb Ferris and Saied Mirshahidi},
  journal={Immunology},
  year={2010},
  volume={129 1},
  pages={
          1-7
        }
}
T cells recognize antigen via the T-cell receptor (TCR) and produce a spectrum of responses that range from activation to anergy or cell death. The variety of outcomes may be dictated by the strength of the signals transmitted upon cognate recognition of the TCR. The physiological outcome of TCR engagement is determined by several factors, including the avidity of the ligand for TCR, the duration of engagement, and the presence and nature of accessory molecules present on antigen-presenting… CONTINUE READING
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