Suboptimal activation of melanoma infiltrating lymphocytes (TIL) due to low avidity of TCR/MHC-tumor peptide interactions

@article{Gervois1996SuboptimalAO,
  title={Suboptimal activation of melanoma infiltrating lymphocytes (TIL) due to low avidity of TCR/MHC-tumor peptide interactions},
  author={Nadine Gervois and Yannik Guilloux and Elisabeth Diez and Francine Jotereau},
  journal={The Journal of Experimental Medicine},
  year={1996},
  volume={183},
  pages={2403 - 2407}
}
Coculture of melanoma cells and T cell clones derived from tumor-infiltrating lymphocytes (TIL) generally results in lysis of the antigen-bearing tumor cells but to inefficient proliferation and IL-2 secretion by responder T cells. This suboptimal activation is classically explained by an inability of tumor cells to provide costimulatory signals. Here we analyzed the responses to synthetic peptides of HLA-A2.1-restricted CTL clones specific for melanoma antigens MART-1 and NA17-A. We showed… CONTINUE READING
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A new gene coding for a differentiation antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas

  • P. G. Coulie, V. Brichard, +8 authors T. Boon
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