Subnuclear positioning and interchromosomal clustering of the GAL1-10 locus are controlled by separable, interdependent mechanisms

@inproceedings{Brickner2016SubnuclearPA,
  title={Subnuclear positioning and interchromosomal clustering of the GAL1-10 locus are controlled by separable, interdependent mechanisms},
  author={Donna Garvey Brickner and Varun Sood and Evelina Tutucci and Robert Coukos and Kayla Viets and Robert H Singer and Jason H Brickner},
  booktitle={Molecular biology of the cell},
  year={2016}
}
On activation, the GAL genes in yeast are targeted to the nuclear periphery through interaction with the nuclear pore complex. Here we identify two cis-acting "DNA zip codes" from the GAL1-10 promoter that are necessary and sufficient to induce repositioning to the nuclear periphery. One of these zip codes, GRS4, is also necessary and sufficient to promote clustering of GAL1-10 alleles. GRS4, and to a lesser extent GRS5, contribute to stronger expression of GAL1 and GAL10 by increasing the… CONTINUE READING
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