Subnuclear Compartmentalization of Immunoglobulin Loci During Lymphocyte Development

@article{Kosak2002SubnuclearCO,
  title={Subnuclear Compartmentalization of Immunoglobulin Loci During Lymphocyte Development},
  author={S. Kosak and J. Skok and K. Medina and R. Riblet and M. L. Le Beau and A. Fisher and H. Singh},
  journal={Science},
  year={2002},
  volume={296},
  pages={158 - 162}
}
Immunoglobulin (Ig) loci are selectively activated for transcription and rearrangement during B lymphocyte development. Using fluorescence in situ hybridization, we show that Ig heavy (H) and Igκ loci are preferentially positioned at the nuclear periphery in hematopoietic progenitors and pro-T cells but are centrally configured in pro-B nuclei. The inactive loci at the periphery do not associate with centromeric heterochromatin. Upon localization away from the nuclear periphery in pro-B cells… Expand
713 Citations
The IGH locus relocalizes to a “recombination compartment” in the perinucleolar region of differentiating B-lymphocytes
  • 4
  • Highly Influenced
  • PDF
Nuclear positioning rather than contraction controls ordered rearrangements of immunoglobulin loci
  • 7
  • PDF
Epigenetic ontogeny of the Igk locus during B cell development
  • 160
  • PDF
Allelic exclusion of the immunoglobulin heavy chain locus is independent of its nuclear localization in mature B cells
  • 28
  • Highly Influenced
  • PDF
Peripheral subnuclear positioning suppresses Tcrb recombination and segregates Tcrb alleles from RAG2
  • 29
  • PDF
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 19 REFERENCES
Nonequivalent nuclear location of immunoglobulin alleles in B lymphocytes
  • 217
V(D)J recombination: molecular biology and regulation.
  • 473
Stepwise activation of the immunoglobulin μ heavy chain gene locus
  • 225
Stimulation of V(D)J recombination by histone acetylation
  • 129
...
1
2
...