Subnanosecond Electric Pulses Cause Membrane Permeabilization and Cell Death

  title={Subnanosecond Electric Pulses Cause Membrane Permeabilization and Cell Death},
  author={Shu Xiao and Siqi Guo and Vasyl Nesin and Richard Heller and Karl H. Schoenbach},
  journal={IEEE Transactions on Biomedical Engineering},
Subnanosecond electric pulses (200 ps) at electric field intensities on the order of 20 kV/cm cause the death of B16.F10 murine melanoma cells when applied for minutes with a pulse repetition rate of 10 kHz. The lethal effect of the ultrashort pulses is found to be caused by a combination of thermal effects and electrical effects. Studies on the cellular level show increased transport across the membrane at much lower exposure times or number of pulses. Exposed to 2000 pulses, NG108 cells… CONTINUE READING
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