Submucosal glands are the predominant site of CFTR expression in the human bronchus

@article{Engelhardt1992SubmucosalGA,
  title={Submucosal glands are the predominant site of CFTR expression in the human bronchus},
  author={John F. Engelhardt and James R. Yankaskas and Stephen A. Ernst and Yiping Yang and Christopher R. Marino and Richard C. Boucher and Jonathan A. Cohn and J. M. Wilson},
  journal={Nature Genetics},
  year={1992},
  volume={2},
  pages={240-248}
}
We have used in situ hybridization and immunocytochemistry to characterize the cellular distribution of cystic fibrosis (CF) gene expression in human bronchus. The cystic fibrosis transmembrane conductance regulator (CFTR) was primarily localized to cells of submucosal glands in bronchial tissues from non–CF individuals notably in the serous component of the secretory tubules as well as a subpopulation of cells in ducts. Normal distribution of CFTR mRNA was found in CF tissues while expression… CONTINUE READING
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