Submolecular cooperativity produces multi-state protein unfolding and refolding.

@article{Englander2002SubmolecularCP,
  title={Submolecular cooperativity produces multi-state protein unfolding and refolding.},
  author={S. Walter Englander and Leland Mayne and Jon N Rumbley},
  journal={Biophysical chemistry},
  year={2002},
  volume={101-102},
  pages={57-65}
}
Hydrogen exchange experiments show that cytochrome c and other proteins under native conditions reversibly unfold in a multi-step manner. The step from one intermediate to the next is determined by the intrinsically cooperative nature of secondary structural elements, which is retained in the native protein. Folding uses the same pathway in the reverse… CONTINUE READING