Submicroscopic Chromosomal Copy Number Variations Identified in Children With Hypoplastic Left Heart Syndrome

@article{Payne2012SubmicroscopicCC,
  title={Submicroscopic Chromosomal Copy Number Variations Identified in Children With Hypoplastic Left Heart Syndrome},
  author={Ashleigh R. Payne and Sheng-Wei Chang and Sara N Koenig and Andrew R. Zinn and Vidu Garg},
  journal={Pediatric Cardiology},
  year={2012},
  volume={33},
  pages={757-763}
}
Hypoplastic left heart syndrome (HLHS), one of the most severe types of congenital heart disease (CHD), results in significant morbidity and mortality despite surgical palliation. The etiology of HLHS is unknown, but evidence supports genetic contributors. The authors hypothesized that submicroscopic chromosomal abnormalities exist in individuals with HLHS and are more frequent in those with additional birth defects. This study sought to determine the incidence and genomic location of… CONTINUE READING
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