Submaximal PPARγ activation and endothelial dysfunction: new perspectives for the management of cardiovascular disorders.

Abstract

PPARγ activation plays an important role in glucose metabolism by enhancing insulin sensitization. PPARγ is a primary target for thiazolidinedione-structured insulin sensitizers like pioglitazone and rosiglitazone employed for the treatment of type 2 diabetes mellitus. Additionally, PPARγ activation inhibits adhesion cascades and detrimental vascular… (More)
DOI: 10.1111/j.1476-5381.2012.01938.x

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