Submaximal PPARγ activation and endothelial dysfunction: new perspectives for the management of cardiovascular disorders

  title={Submaximal PPAR$\gamma$ activation and endothelial dysfunction: new perspectives for the management of cardiovascular disorders},
  author={Pitchai Balakumar and Sonam Kathuria},
  journal={British Journal of Pharmacology},
PPARγ activation plays an important role in glucose metabolism by enhancing insulin sensitization. PPARγ is a primary target for thiazolidinedione‐structured insulin sensitizers like pioglitazone and rosiglitazone employed for the treatment of type 2 diabetes mellitus. Additionally, PPARγ activation inhibits adhesion cascades and detrimental vascular inflammatory events. Importantly, activation of PPARγ plays a distinctive role in regulating the physiology and expression of endothelial nitric… 
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    Current pharmaceutical design
  • 2019
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