Submaximal ADP-stimulated respiration is impaired in ZDF rats and recovered by resveratrol.


Mitochondrial dysfunction and reactive oxygen species (ROS) have been implicated in the aetiology of skeletal muscle insulin resistance, although there is considerable controversy regarding these concepts. Mitochondrial function has been traditionally assessed in the presence of saturating ADP, but ATP turnover and the resultant ADP is thought to limit… (More)
DOI: 10.1113/jphysiol.2013.259226