Sublingual targeting of STING with 3'3'-cGAMP promotes systemic and mucosal immunity against anthrax toxins.

@article{Martin2017SublingualTO,
  title={Sublingual targeting of STING with 3'3'-cGAMP promotes systemic and mucosal immunity against anthrax toxins.},
  author={Tara Laine Martin and Junbae Jee and Eunsoo Kim and Haley E Steiner and Estelle Cormet-Boyaka and Prosper N Boyaka},
  journal={Vaccine},
  year={2017},
  volume={35 18},
  pages={
          2511-2519
        }
}
Anthrax is caused by Bacillus anthracis, a zoonotic bacterial pathogen affecting humans and livestock worldwide. The current human anthrax vaccine, anthrax vaccine adsorbed (AVA), is an injected vaccine with a cumbersome administration schedule and fails to promote mucosal immunity. Bacterial enterotoxins, which stimulate production of the cyclic nucleotide cAMP are effective experimental mucosal vaccine adjuvants, but their inherent toxicity has precluded their use in humans. We investigated… CONTINUE READING