Sublingual epinephrine tablets versus intramuscular injection of epinephrine: dose equivalence for potential treatment of anaphylaxis.

@article{RawasQalaji2006SublingualET,
  title={Sublingual epinephrine tablets versus intramuscular injection of epinephrine: dose equivalence for potential treatment of anaphylaxis.},
  author={Mutasem M. Rawas-Qalaji and F. Estelle R. Simons and Keith J. Simons},
  journal={The Journal of allergy and clinical immunology},
  year={2006},
  volume={117 2},
  pages={398-403}
}
BACKGROUND Epinephrine autoinjectors are underused in the emergency treatment of anaphylaxis in the community, perhaps in part because of fear of needles. OBJECTIVES To determine the sublingual epinephrine dose from a novel fast-disintegrating tablet required to achieve epinephrine plasma concentrations (EPPCs) similar to those obtained after epinephrine 0.3 mg intramuscular injection. METHODS In a prospective 5-way crossover study, sublingual tablets containing epinephrine 0, 10, 20, and… CONTINUE READING
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