Sublingual delivery of insulin: effects of enhancers on the mucosal lipid fluidity and protein conformation, transport, and in vivo hypoglycemic activity.

@article{Cui2005SublingualDO,
  title={Sublingual delivery of insulin: effects of enhancers on the mucosal lipid fluidity and protein conformation, transport, and in vivo hypoglycemic activity.},
  author={Chun-Ying Cui and Wan-liang Lu and Lan Xiao and Shuaishuai Zhang and Yan-Bei Huang and Sheng-lin Li and Rui-juan Zhang and Guangting Wang and Xuan Zhang and Qiang Zhang},
  journal={Biological & pharmaceutical bulletin},
  year={2005},
  volume={28 12},
  pages={
          2279-88
        }
}
The purposes of this study were to evaluate effects of enhancers for sublingual delivering insulin on the mucosal lipid fluidity and protein conformation, transport, and in vivo hypoglycemic activity in normal rats. The effects on sublingual mucosa, and aggregation states of insulin were estimated using fluorescence polarization, and circular dichroism method, respectively. The human immortalized oral epithelial cell monolayer was used for evaluating transport of insulin. Hydroxylpropyl-beta… CONTINUE READING

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