Sublethal irradiation promotes invasiveness of neuroblastoma cells.

  title={Sublethal irradiation promotes invasiveness of neuroblastoma cells.},
  author={Lothar L Schweigerer and Margret Rave-Fr{\"a}nk and Heinz Schmidberger and Monica Hecht},
  journal={Biochemical and biophysical research communications},
  volume={330 3},
Neuroblastoma is the most frequent extracranial solid tumour of childhood. Despite multiple clinical efforts, clinical outcome has remained poor. Neuroblastoma is considered to be radiosensitive, but some clinical studies including the German trial NB90 failed to show a clinical benefit of radiation therapy. The mechanisms underlying this apparent… CONTINUE READING