Sublethal cadmium intoxication in Arabidopsis thaliana impacts translation at multiple levels.

@article{Sormani2011SublethalCI,
  title={Sublethal cadmium intoxication in Arabidopsis thaliana impacts translation at multiple levels.},
  author={Rodnay Sormani and Etienne Delannoy and S{\'e}bastien Lageix and Fr{\'e}d{\'e}rique Bitton and Elodie Lanet and Julio S{\'a}ez-V{\'a}squez and Jean Marc Deragon and Jean Pierre Renou and Christophe Robaglia},
  journal={Plant & cell physiology},
  year={2011},
  volume={52 2},
  pages={436-47}
}
To study the impact of translational regulation during heavy metal poisoning, Arabidopsis thaliana cell cultures were submitted to sublethal cadmium stress. At the concentration used, cadmium had a minimal impact on the growth of the culture but induced an accumulation of high molecular weight polysomes without de novo production of new ribosomes together with a reduction of protein synthesis. In addition, cadmium stress induces phosphorylation of eukaryotic initiation factor 2α by GCN2 and, in… CONTINUE READING

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