Subjective cognitive decline and subsequent dementia: a nationwide cohort study of 579,710 people aged 66 years in South Korea

  title={Subjective cognitive decline and subsequent dementia: a nationwide cohort study of 579,710 people aged 66 years in South Korea},
  author={Yeong Chan Lee and Jae Myeong Kang and Hyewon Lee and Kiwon Kim and Soyeon Kim and Tae Yang Yu and Eun-Mi Lee and Clara Tammy Kim and Doh-Kwan Kim and Matthew Lewis and Hong-Hee Won and Frank Jessen and Woojae Myung},
  journal={Alzheimer's Research \& Therapy},
Background Subjective cognitive decline (SCD) is a potential risk factor for dementia. We aimed to investigate the association between SCD and subsequent dementia in a nationwide population-based cohort in South Korea. Methods This cohort included 579,710 66-year-old adults who were followed for a total of 3,870,293 person-years (average 6.68 ± 1.33 years per person). All subjects completed a questionnaire about subjective memory impairment, the Pre-screening Korean Dementia Screening… 
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Findings add to the growing literature to suggest that the degree of functional impairment at baseline is an important predictor of conversion to dementia and may help explain differences in findings between epidemiological and clinic-based studies.
Gender differences in the prodromal signs of dementia: memory complaint and IADL-restriction. a prospective population-based cohort.
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Cognitive self-report measures used by 19 SCD-I Working Group studies, representing 8 countries and 5 languages, are compared to offer preliminary recommendations for instrument selection and future research directions including identifying items and measure formats associated with important clinical outcomes.
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In MCI, specific aspects of SCD severity and quality are related to CSF biomarker signature indicative of prodromal AD together with either high CSF tau or CSF phosphorylated tau 181 levels.
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The prediction of dementia in AD by SMI with subsequent amnestic MCI supports the model of a consecutive 3-stage clinical manifestation of AD from SMI via MCI to dementia.
Association of subjective memory complaints with subsequent cognitive decline in community-dwelling elderly individuals with baseline cognitive impairment.
Memory complaints may lack validity in subjects with normal cognition, but in nondemented individuals with cognitive impairment, memory complaints may predict subsequent cognitive decline.
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Compared the prevalence and identified common determinants of abnormal AD biomarkers in SCD across three European memory clinics participating in the European initiative on harmonization of SCD in preclinical AD (Euro-SCD), finding heterogeneous frequency of abnormal Aβ42 was partly explained by between-sample differences in age range and APOE status.
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Depression and DM were independently associated with a greater risk for dementia, and the combined association of both exposures with the risk for all-cause dementia was stronger than the additive association.