Subjective cognitive concerns, amyloid-β, and neurodegeneration in clinically normal elderly.

@article{Amariglio2015SubjectiveCC,
  title={Subjective cognitive concerns, amyloid-β, and neurodegeneration in clinically normal elderly.},
  author={Rebecca E. Amariglio and Elizabeth C. Mormino and Alison Camille Pietras and Gad A. Marshall and Patrizia Vannini and Keith A. Johnson and Reisa A. Sperling and Dorene M. Rentz},
  journal={Neurology},
  year={2015},
  volume={85 1},
  pages={56-62}
}
OBJECTIVE To determine whether neuroimaging biomarkers of amyloid-β (Aβ) and neurodegeneration (ND) are associated with greater self-reported subjective cognitive concerns (SCC) in clinically normal older individuals. METHODS A total of 257 participants underwent Pittsburgh compound B PET, PET with fluorodeoxyglucose (18)F, and structural MRI, as well as a battery of neuropsychological measures including several questionnaires regarding SCC. Individuals were classified into 4 biomarker groups… CONTINUE READING
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A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer ’ s disease

  • F Jessen, RE Amariglio, M vanBoxtel
  • Alzheimers Dement
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