Subjective and physiological responses among racemic-methadone maintenance patients in relation to relative (S)- vs. (R)-methadone exposure.

@article{Mitchell2004SubjectiveAP,
  title={Subjective and physiological responses among racemic-methadone maintenance patients in relation to relative (S)- vs. (R)-methadone exposure.},
  author={Timothy B. Mitchell and Kyle R. Dyer and David A L Newcombe and Amy Salter and Andrew A Somogyi and Felix Bochner and Jason Martin White},
  journal={British journal of clinical pharmacology},
  year={2004},
  volume={58 6},
  pages={
          609-17
        }
}
AIMS To investigate the possibility that (S)-methadone influences therapeutic and adverse responses to rac-methadone maintenance treatment, by examining how subjective and physiological responses among rac-methadone maintenance patients vary in relation to relative exposure to (S)- vs. (R)-methadone. METHODS Mood states (Profile of Mood States), opioid withdrawal (Methadone Symptoms Checklist), physiological responses (pupil diameter, heart rate, respiration rate, blood pressure), and plasma… CONTINUE READING

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