Subjective and objective sensory responses to inhalation of nitrous oxide and methoxyflurane.

@article{Tomlin1973SubjectiveAO,
  title={Subjective and objective sensory responses to inhalation of nitrous oxide and methoxyflurane.},
  author={Peter J. Tomlin and B. C. Jones and Robert P. Edwards and Pierre Robin},
  journal={British journal of anaesthesia},
  year={1973},
  volume={45 7},
  pages={
          719-25
        }
}
An investigation, in volunteers, into the sensory effects of nitrous oxide and methoxyflurane showed that the subjective changes of reduction in visual awareness and heightened auditory awareness were not supported by objective measurement. Vision remained normal until the subjects became unresponsive, whilst hearing was in fact diminished. The analgesia produced by nitrous oxide was late in appearance relative to the other sensory changes and it disappeared very rapidly upon recovery. In… 

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References

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It is suggested that the general increase in sensory thresholds produced by nitrous oxide is a sufficient explanation of the disturbances of memory and time sense that have been observed withNitrous oxide inhalation.