Subinhibitory cerulenin inhibits staphylococcal exoprotein production by blocking transcription rather than by blocking secretion.

@article{Adhikari2005SubinhibitoryCI,
  title={Subinhibitory cerulenin inhibits staphylococcal exoprotein production by blocking transcription rather than by blocking secretion.},
  author={Rajan P. Adhikari and Richard P. Novick},
  journal={Microbiology},
  year={2005},
  volume={151 Pt 9},
  pages={3059-69}
}
Cerulenin is an antibiotic that inhibits fatty acid synthesis by covalent modification of the active thiol of the chain-elongation subtypes of beta-ketoacyl-acyl carrier protein synthase. It also inhibits other processes that utilize essential thiols. Cerulenin has been widely reported to block protein secretion at sub-MIC levels, an effect that has been postulated to represent interference with membrane function through interference with normal fatty acid synthesis. This study confirms the… CONTINUE READING
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