Subinfectious Hepatitis C Virus Exposures Suppress T cell Responses Against Subsequent Acute Infection

  title={Subinfectious Hepatitis C Virus Exposures Suppress T cell Responses Against Subsequent Acute Infection},
  author={Su–Hyung Park and Naga Suresh Veerapu and Eui–Cheol Shin and Ang{\'e}lique Biancotto and J. Philip McCoy and Stefania Capone and Antonella Folgori and Barbara Rehermann},
  booktitle={Nature Medicine},
Hepatitis C virus (HCV) is endemic in many countries due to its high propensity for establishing persistence. The presence of HCV-specific T cells in subjects repeatedly exposed to HCV who test negative for HCV RNA and antibodies and who do not have any history of HCV infection has been interpreted as T cell–mediated protection. Here, we show in nonhuman primates that repeated exposure to human plasma with trace amounts of HCV induced HCV-specific T cells without seroconversion and systemic… CONTINUE READING
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