Subiculum network excitability is increased in a rodent model of temporal lobe epilepsy.

@article{Guzman2006SubiculumNE,
  title={Subiculum network excitability is increased in a rodent model of temporal lobe epilepsy.},
  author={Philip H de Guzman and Yuji Inaba and Giuseppe Biagini and Enrica Baldelli and Cristiana Mollinari and Daniela Merlo and Massimo Avoli},
  journal={Hippocampus},
  year={2006},
  volume={16 10},
  pages={843-60}
}
In this study, we used in vitro electrophysiology along with immunohistochemistry and molecular techniques to study the subiculum--a limbic structure that gates the information flow from and to the hippocampus--in pilocarpine-treated epileptic rats. Comparative data were obtained from age-matched nonepileptic controls (NEC). Subicular neurons in hippocampal-entorhinal cortex (EC) slices of epileptic rats were: (i) hyperexcitable when activated by CA1 or EC inputs; and (ii) generated spontaneous… CONTINUE READING

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