Subgroups of variable region genes of beta chains of T-cell receptors for antigen.

@article{Schiffer1986SubgroupsOV,
  title={Subgroups of variable region genes of beta chains of T-cell receptors for antigen.},
  author={Marianne Schiffer and Tai Te Wu and Elvin A. Kabat},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1986},
  volume={83 12},
  pages={
          4461-3
        }
}
The beta-chain variable regions of 6 human, 21 mouse, and 1 rabbit T-cell receptors for antigen, including two pairs of duplicates, have been classified into two subgroups. Subgroup I has an invariant Phe at residue 65 and a salt bridge can be formed between the Asp at position 86 and the 11 Arg, 2 Lys, and 1 His residues at position 64. In one instance Tyr replaces Asp at position 86 so that a salt bridge cannot be formed with the Lys at position 64. Subgroup II has an invariant Tyr at residue… CONTINUE READING

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