Subgroup of reproductive functions of progesterone mediated by progesterone receptor-B isoform.

@article{MulacJericevic2000SubgroupOR,
  title={Subgroup of reproductive functions of progesterone mediated by progesterone receptor-B isoform.},
  author={Biserka Mulac-Jericevic and R A Mullinax and Francesco J. Demayo and John P. Lydon and Orla M. Conneely},
  journal={Science},
  year={2000},
  volume={289 5485},
  pages={1751-4}
}
Progesterone regulates reproductive function through two intracellular receptors, progesterone receptor-A (PR-A) and progesterone receptor-B (PR-B), that arise from a single gene and function as transcriptional regulators of progesterone-responsive genes. Although in vitro studies show that PR isoforms can display different transcriptional regulatory activities, their physiological significance is unknown. By selective ablation of PR-A in mice, we show that the PR-B isoform modulates a subset… CONTINUE READING

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