Subgroup analysis and covariate adjustment in randomized clinical trials of traumatic brain injury: a systematic review.

@article{Hernndez2005SubgroupAA,
  title={Subgroup analysis and covariate adjustment in randomized clinical trials of traumatic brain injury: a systematic review.},
  author={Adri{\'a}n V Hern{\'a}ndez and Ewout Willem Steyerberg and G. G. Stopford Taylor and Anthony Marmarou and J. Dik F. Habbema and Andrew I. R. Maas},
  journal={Neurosurgery},
  year={2005},
  volume={57 6},
  pages={
          1244-53; discussion 1244-53
        }
}
OBJECTIVE Few randomized clinical trials (RCTs) in the field of traumatic brain injury (TBI) have shown a significant treatment benefit. We critically reviewed the use of two types of secondary analyses, covariate adjustment and subgroup analysis, which are common in TBI trials. METHODS We performed a systematic review of therapeutic phase III RCTs, including adult patients with acute, moderate-to-severe TBI. Glasgow Outcome Scale (GOS) at > or =3 months as outcome, and > or =50 patients per… CONTINUE READING
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