Subgenomic negative-strand RNA function during mouse hepatitis virus infection.

  title={Subgenomic negative-strand RNA function during mouse hepatitis virus infection.},
  author={Ralph S. Baric and Boyd L. Yount},
  journal={Journal of virology},
  volume={74 9},
Mouse hepatitis virus (MHV)-infected cells contain full-length and subgenomic-length positive- and negative-strand RNAs. The origin and function of the subgenomic negative-strand RNAs is controversial. In this report we demonstrate that the synthesis and molar ratios of subgenomic negative strands are similar in alternative host cells, suggesting that these RNAs function as important mediators of positive-strand synthesis. Using kinetic labeling experiments, we show that the full-length and… CONTINUE READING

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