Subgenomic messenger RNAs: mastering regulation of (+)-strand RNA virus life cycle.

@article{SztubaSoliska2011SubgenomicMR,
  title={Subgenomic messenger RNAs: mastering regulation of (+)-strand RNA virus life cycle.},
  author={Joanna Sztuba-Solińska and Victor Stollar and Jozef J. Bujarski},
  journal={Virology},
  year={2011},
  volume={412 2},
  pages={245-55}
}
Many (+)-strand RNA viruses use subgenomic (SG) RNAs as messengers for protein expression, or to regulate their viral life cycle. Three different mechanisms have been described for the synthesis of SG RNAs. The first mechanism involves internal initiation on a (-)-strand RNA template and requires an internal SGP promoter. The second mechanism makes a prematurely terminated (-)-strand RNA which is used as template to make the SG RNA. The third mechanism uses discontinuous RNA synthesis while… CONTINUE READING