Subfunctionalization of POMC paralogues in Senegalese sole (Solea senegalensis).

@article{Wunderink2012SubfunctionalizationOP,
  title={Subfunctionalization of POMC paralogues in Senegalese sole (Solea senegalensis).},
  author={Yvette S. Wunderink and Erik de Vrieze and Juriaan Rogier Metz and Silke Halm and Gonzalo Mart{\'i}nez-Rodr{\'i}guez and Gert Flik and Peter H M Klaren and Juan Miguel Mancera},
  journal={General and comparative endocrinology},
  year={2012},
  volume={175 3},
  pages={407-15}
}
The precursor protein proopiomelanocortin (POMC) gives rise to a variety of biologically active peptides through cell-specific posttranslational processing. Two transcripts of pomc were found in the flatfish Solea senegalensis (ssePOMC-A and ssePOMC-B), that most likely represent subfunctionalized paralogues: ssePOMC-A lacks the N-terminal cleavage site for β-MSH, whereas ssePOMC-B cannot yield ACTH and completely lacks the opioid consensus sequence in the β-END region. An analysis of… CONTINUE READING

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