Subfornical organ mediates sympathetic and hemodynamic responses to blood-borne proinflammatory cytokines.

@article{Wei2013SubfornicalOM,
  title={Subfornical organ mediates sympathetic and hemodynamic responses to blood-borne proinflammatory cytokines.},
  author={S H Wei and Z Zhang and Terry G. Beltz and Yonghao Yu and Alan Kim Johnson and Robert B Felder},
  journal={Hypertension},
  year={2013},
  volume={62 1},
  pages={118-25}
}
Proinflammatory cytokines play an important role in regulating autonomic and cardiovascular function in hypertension and heart failure. Peripherally administered proinflammatory cytokines, such as tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), act on the brain to increase blood pressure, heart rate, and sympathetic nerve activity. These molecules are too large to penetrate the blood-brain barrier, and so the mechanisms by which they elicit these responses remain unknown. We tested… CONTINUE READING