Subfertility in androgen-insensitive female mice is rescued by transgenic FSH.

  title={Subfertility in androgen-insensitive female mice is rescued by transgenic FSH.},
  author={Kirsty A. Walters and Melissa C Edwards and Mark Jimenez and David J Handelsman and Charles M. Allan},
  journal={Reproduction, fertility, and development},
  volume={29 7},
Androgens synergise with FSH in female reproduction but the nature of their interaction in ovarian function and fertility is not clear. In the present study, we investigated this interaction, notably whether higher endogenous FSH can overcome defective androgen actions in androgen receptor (AR)-knockout (ARKO) mice. We generated and investigated the reproductive function of mutant mice exhibiting AR resistance with or without expression of human transgenic FSH (Tg-FSH). On the background of… CONTINUE READING
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