Subfertility caused by altered follicular development and oocyte growth in female mice lacking PKB alpha/Akt1.

@article{Brown2010SubfertilityCB,
  title={Subfertility caused by altered follicular development and oocyte growth in female mice lacking PKB alpha/Akt1.},
  author={Caitlin W Brown and Jessica LaRocca and Jodie R. Pietruska and Melissa Ota and Linnea M. Anderson and Stuart D. Smith and Paula J. Weston and Teresa Rasoulpour and Mary L. Hixon},
  journal={Biology of reproduction},
  year={2010},
  volume={82 2},
  pages={
          246-56
        }
}
Mammalian females are endowed with a finite number of primordial follicles at birth. Immediately following formation of the primordial follicle pool, cohorts of follicles are either culled from the ovary or are recruited to grow until the primordial follicle population is depleted. The majority of ovarian follicles, including the oocytes, undergo atresia through apoptotic cell death. As PKB alpha/Akt1 is known to regulate apoptosis, we asked whether Akt1 functioned in the regulation of… CONTINUE READING

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