Suberoylanilide hydroxamic acid induces Akt-mediated phosphorylation of p300, which promotes acetylation and transcriptional activation of RelA/p65.

@article{Liu2006SuberoylanilideHA,
  title={Suberoylanilide hydroxamic acid induces Akt-mediated phosphorylation of p300, which promotes acetylation and transcriptional activation of RelA/p65.},
  author={Yuan Liu and Chadrick E. Denlinger and Brian K Rundall and P. W. Smith and David R. Jones},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 42},
  pages={31359-68}
}
We have previously demonstrated that the transcription factor NF-kappaB is activated by histone deacetylase inhibitors in a PI3K/Akt-dependent manner. The molecular mechanisms governing this process have not been well described. By virtue of their inhibitory action, it is unclear whether the addition of histone deacetylase inhibitors simply preserves the… CONTINUE READING