Suberoylanilide hydroxamic acid (SAHA) induces apoptosis or autophagy-associated cell death in chondrosarcoma cell lines.

@article{Yamamoto2008SuberoylanilideHA,
  title={Suberoylanilide hydroxamic acid (SAHA) induces apoptosis or autophagy-associated cell death in chondrosarcoma cell lines.},
  author={Shunsaku Yamamoto and Kazuhiro Tanaka and Riku Sakimura and Takamitsu Okada and Tomoyuki Nakamura and Yan Li and Minoru Takasaki and Yusaku Nakabeppu and Yukihide Iwamoto},
  journal={Anticancer research},
  year={2008},
  volume={28 3A},
  pages={1585-91}
}
BACKGROUND Since chondrosarcoma has a high resistance to conventional chemotherapy and radiotherapy, surgical resection is currently the only effective treatment. Histone deacetylase (HDAC) inhibitor exert anticancer effects, but have not been tested in chondrosarcoma. MATERIALS AND METHODS We investigated the phenotypic change in chondrosarcoma cells treated with SAHA by cell viability assay, Western blot, flow cytometric analysis and electron microscopy. RESULTS SAHA inhibited the growth… CONTINUE READING

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