Subdomain IIIA of Dog Albumin Contains a Binding Site Similar to Site II of Human Albumin

@article{Kaneko2008SubdomainIO,
  title={Subdomain IIIA of Dog Albumin Contains a Binding Site Similar to Site II of Human Albumin},
  author={Ken-ichi Kaneko and Hikaru Fukuda and Victor Tuan Giam Chuang and Keishi Yamasaki and Kohichi Kawahara and Hitoshi Nakayama and Ayaka Suenaga and Toru Maruyama and Masaki Otagiri},
  journal={Drug Metabolism and Disposition},
  year={2008},
  volume={36},
  pages={81 - 86}
}
Dog albumin contains a specific drug-binding site that binds most of the site II ligands of human albumin. This study was undertaken to elucidate the structural configuration of this binding site using a photoaffinity labeling technique. Dog albumin and albumins of other animal species were photolabeled with [14C]ketoprofen. The photolabeled albumins were cleaved with cyanogen bromide (CNBr) and analyzed autoradiographically after electrophoretic separation. A 11.6-kDa CNBr fragment of the… 
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