Subdiffusion Supports Joining Of Correct Ends During Repair Of DNA Double-Strand Breaks

  title={Subdiffusion Supports Joining Of Correct Ends During Repair Of DNA Double-Strand Breaks},
  author={Stefanie Girst and V. Hable and Guido A. Drexler and C Greubel and Christian Siebenwirth and M. Haum and Anna A. Friedl and Guenther Dollinger},
  booktitle={Scientific reports},
The mobility of damaged chromatin regions in the nucleus may affect the probability of mis-repair. In this work, live-cell observation and distance tracking of GFP-tagged DNA damage response protein MDC1 was used to study the random-walk behaviour of chromatin domains containing radiation-induced DNA double-strand breaks (DSB). Our measurements indicate a subdiffusion-type random walk process with similar time dependence for isolated and clustered DSBs that were induced by 20 MeV proton or 43… CONTINUE READING
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