Subdiaphragmatic vagotomy does not influence the anorectic effect of amylin

  title={Subdiaphragmatic vagotomy does not influence the anorectic effect of amylin},
  author={Thomas A Lutz and Ernesto Del Prete and Erwin Scharrer},
Amylin injected IP reduced food intake for 2-4 h in subdiaphragmatically vagotomized and in sham-vagotomized rats. The magnitude of the anorectic effect of 0.5 microgram/kg amylin was similar to that of 2.5 micrograms/kg amylin but the duration of the effect was somewhat shorter with the low dose. Amylin (1 microgram/kg, IP) had no influence on gastric emptying. In conclusion, the hypophagic effect of peripherally administered amylin does not depend on an intact abdominal vagus or on an… CONTINUE READING
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Anorectic effect of amylin is not transmitted by capsaicin-sensitive nerve fibers.

American journal of physiology. Regulatory, integrative and comparative physiology • 1998
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