Subcutaneous adipose tissue-derived stem cells facilitate colonic mucosal recovery from 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis in rats.

@article{Ando2008SubcutaneousAT,
  title={Subcutaneous adipose tissue-derived stem cells facilitate colonic mucosal recovery from 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis in rats.},
  author={Yugo Ando and Muneo Inaba and Yutaku Sakaguchi and Masanobu Tsuda and Guo Ke Quan and Mariko Omae and Kazuichi Okazaki and Susumu Ikehara},
  journal={Inflammatory bowel diseases},
  year={2008},
  volume={14 6},
  pages={
          826-38
        }
}
BACKGROUND Adipose tissue-derived stem cells (ADSCs) can be easily obtained from subcutaneous adipose tissue, and ADSCs can be demonstrated to display multilineage developmental plasticity. In this study, using TNBS-induced colitis rats, we show the feasibility of repairing injured intestinal mucosa with adipose tissue-derived stem cells. METHODS The subcutaneous adipose tissue of F344 rats was obtained and digested by collagenase. The digested tissue was cultured in DMEM containing 10% FBS… CONTINUE READING