Subcutaneous absorption kinetics of two highly concentrated preparations of recombinant human growth hormone.


OBJECTIVE The relative bioavailability of two highly concentrated (12 IU/ml) formulations of biosynthetic human growth hormone (GH) administered subcutaneously was compared. DESIGN A randomized, crossover study. Conventional GH therapy was withdrawn 72 hours before each study period. There was a washout period of at least four weeks between the study… (More)