Subcutaneous Nogo receptor removes brain amyloid-beta and improves spatial memory in Alzheimer's transgenic mice.

@article{Park2006SubcutaneousNR,
  title={Subcutaneous Nogo receptor removes brain amyloid-beta and improves spatial memory in Alzheimer's transgenic mice.},
  author={James Hugh Park and Gabriel Antonio Widi and David Adam Gimbel and Noam Y Harel and Daniel Hong Seng Lee and Stephen M Strittmatter},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2006},
  volume={26 51},
  pages={13279-86}
}
The production and aggregation of cerebral amyloid-beta (Abeta) peptide are thought to play a causal role in Alzheimer's disease (AD). Previously, we found that the Nogo-66 receptor (NgR) interacts physically with both Abeta and the amyloid precursor protein (APP). The inverse correlation of Abeta levels with NgR levels within the brain may reflect regulation of Abeta production and/or Abeta clearance. Here, we assess the potential therapeutic benefit of peripheral NgR-mediated Abeta clearance… CONTINUE READING

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The Journal of neuroscience : the official journal of the Society for Neuroscience • 2006
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