Subcutaneous Apomorphine in Parkinsonian On-off Oscillations

  title={Subcutaneous Apomorphine in Parkinsonian On-off Oscillations},
  author={C M Stibe and Peter Kempster and A. J. Lees and Gerald M Stern},
  journal={The Lancet},
Subcutaneous apomorphine, a dopamine agonist, was given by continuous infusion during the day or by repeated injections to 19 patients with Parkinson's disease disabled by severe on-off fluctuations. All patients were also given domperidone. The 11 patients treated by infusion showed marked and sustained improvement, and their mean duration of daily off periods over a period of 15 months fell by 6.3 h; similar results were obtained in 8 patients with less severe disabilities who were given… CONTINUE READING


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