Subcortical motor plasticity in patients with sporadic ALS: An fMRI study.

  title={Subcortical motor plasticity in patients with sporadic ALS: An fMRI study.},
  author={Alessandro Tessitore and Fabrizio Esposito and Maria Rosaria Monsurr{\`o} and S. Graziano and Daniela Panza and Antonio Russo and Raffaella Migliaccio and Francesca Luisa Conforti and Raffaele Morrone and Aldo Quattrone and Francesco di Salle and Gioacchino Tedeschi},
  journal={Brain research bulletin},
  volume={69 5},
OBJECTIVE To address the potential contribution of subcortical brain regions in the functional reorganization of the motor system in patients with sporadic ALS (sALS) and to investigate whether functional changes in brain activity are different in sALS patients with predominant upper motor neuron (UMN) or lower motor neuron (LMN) dysfunction. METHODS We studied 16 patients with sALS and 13 healthy controls, using BOLD-fMRI, while they performed a simple visually paced motor task. Seven… CONTINUE READING