Subcortical hyperintensities on brain magnetic resonance imaging: a comparison between late age onset and early onset elderly depressed subjects.

@article{Figiel1991SubcorticalHO,
  title={Subcortical hyperintensities on brain magnetic resonance imaging: a comparison between late age onset and early onset elderly depressed subjects.},
  author={Gary S. Figiel and K. Ranga R. Krishnan and P. Murali Doraiswamy and Varada P. Rao and Charles B. Nemeroff and Orest B. Boyko},
  journal={Neurobiology of aging},
  year={1991},
  volume={12 3},
  pages={245-7}
}
Subcortical structural changes have been reported to occur in some elderly subjects with late age onset depression. Given the association between diseases affecting subcortical structures and affective disorders, this suggests that these structural changes may be involved in the etiology of late age onset depression in some patients. With the advent of Brain Magnetic Resonance Imaging (MRI), "in vivo" analysis of these subcortical structures is now possible. The authors report a higher… CONTINUE READING