Subcortical effects of transcranial direct current stimulation in the rat

  title={Subcortical effects of transcranial direct current stimulation in the rat},
  author={Francesco Bolzoni and Marcin Bączyk and Elzbieta Jankowska},
  journal={The Journal of Physiology},
•  Previously demonstrated facilitation of activation of subcortical neurons by transcranial direct current stimulation (tDCS) in acute experiments on deeply anaesthetized animals was fairly weak. It resulted in only small increases in the amplitude and in a slight shortening of latencies of subcortically initiated descending volleys. •  Here we show that despite weak effects on descending volleys, EMG responses evoked in neck muscles by reticulospinal and rubrospinal neurons in deeply… 
Presynaptic actions of transcranial and local direct current stimulation in the red nucleus
It is shown that presynaptic subcortical actions of tDCS outlast the duration of its application by up to 1 h and may contribute to long‐lasting facilitation of activation of neurons in the red nucleus in experiments on deeply anaesthetized animals.
Subcortical Structures in Humans Can Be Facilitated by Transcranial Direct Current Stimulation
The faster onsets of SAS-induced wrist and ankle movements and automatic postural responses following stimulation provide strong evidence that, in humans, subcortical structures - in particular the reticular formation - can be facilitated by tDCS.
Electrophysiological Effects of Transcranial Direct Current Stimulation on Neural Activity in the Rat Motor Cortex
The primary finding of this study was that both anodal and cathodal tDCS increased in vivo neuronal activity in the rat cerebral cortex underneath the stimulus electrode.
A dissociation between propriospinal facilitation and inhibition after bilateral transcranial direct current stimulation.
M1-M1 tDCS may be a useful adjuvant to techniques that aim to reduce upper limb impairment after stroke and contrary to an earlier study with cathodal tDCS, INH was unchanged across all sessions.
Transcranial direct current stimulation reverses neurophysiological and behavioural effects of focal inhibition of human pharyngeal motor cortex on swallowing
It is shown that application of optimised parameters of tDCS over the unconditioned hemisphere reverses the brain and behavioural consequences of inhibitory pre‐conditioning, supporting the use of tDCs in clinical trials.
Facilitation of ipsilateral actions of corticospinal tract neurons on feline motoneurons by transcranial direct current stimulation
It is indicated that tDCS may increase the contribution of iPT actions to the recovery of motor functions after injuries to coPT neurons, and thereby assist rehabilitation, provided that corticoreticular and reticulospinal connections are preserved.
Cathodal Transcranial Direct Current Stimulation (tDCS) Applied to the Left Premotor Cortex Interferes with Explicit Reproduction of a Motor Sequence
The present data suggest the left premotor cortex as one possible target for the application of non-invasive brain stimulation techniques in explicit motor sequence learning with the right hand.
Animal Studies in the Field of Transcranial Electric Stimulation
This chapter provides a broad introduction to methods and insights from animal models of tDCS/tACS, which may increase brain capacity for plasticity enhancing the effects of neuropsychiatric therapies, and compensating for disease-related decline.
Animal models of transcranial direct current stimulation: Methods and mechanisms


Evidence for long‐lasting subcortical facilitation by transcranial direct current stimulation in the cat
It is shown that transcranial brain polarization in anaesthetized animals not only affects cortical neurons, as is often assumed, but also facilitates activation of neurons in all investigated subcortical motor systems.
Transcranial direct current stimulation induces polarity-specific changes of cortical blood perfusion in the rat
How does transcranial DC stimulation of the primary motor cortex alter regional neuronal activity in the human brain?
TDCS is an effective means of provoking sustained and widespread changes in regional neuronal activity and the extensive spatial and temporal effects of tDCS need to be taken into account when tDCS is used to modify brain function.
Electrophysiological actions of the rubrospinal tract in the anaesthetised rat
Excitability changes induced in the human auditory cortex by transcranial direct current stimulation: direct electrophysiological evidence
Results show that anodal and cathodal tDCS can modify auditory cortex reactivity and directly demonstrate excitability changes in the auditory cortex induced by active tDCS over the temporal and temporo-parietal cortex.
Physiological Basis of Transcranial Direct Current Stimulation
  • C. Stagg, M. Nitsche
  • Psychology, Biology
    The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
  • 2011
The authors bring together the results from these pharmacological, neurophysiological, and imaging studies to describe their current knowledge of the physiological effects of tDCS, and the theoretical framework for how tDCS affects motor learning is proposed.
After-effects of consecutive sessions of transcranial direct current stimulation (tDCS) in a rat model of chronic inflammation
The hypothesis that tDCS induces significant, long-lasting, neuroplastic effects is confirmed and this work expands these findings to a chronic pain model of peripheral inflammation, thus supporting the exploration of this technique in conditions associated with chronic pain and peripheral inflammation.
Contribution of axonal orientation to pathway-dependent modulation of excitatory transmission by direct current stimulation in isolated rat hippocampus.
Transcranial direct current stimulation (tDCS) is a method for modulating cortical excitability by weak constant electrical current that is applied through scalp electrodes. Although often described