Subcortical and ventral prefrontal cortical neural responses to facial expressions distinguish patients with bipolar disorder and major depression

@article{Lawrence2004SubcorticalAV,
  title={Subcortical and ventral prefrontal cortical neural responses to facial expressions distinguish patients with bipolar disorder and major depression},
  author={N. Lawrence and A. Williams and S. Surguladze and V. Giampietro and M. Phillips},
  journal={Biological Psychiatry},
  year={2004},
  volume={55},
  pages={578-587}
}
  • N. Lawrence, A. Williams, +2 authors M. Phillips
  • Published 2004
  • Psychology, Medicine
  • Biological Psychiatry
  • BACKGROUND Bipolar disorder (BD) is characterised by abnormalities in mood and emotional processing, but the neural correlates of these, their relationship to depressive symptoms, and the similarities with deficits in major depressive disorder (MDD) remain unclear. We compared responses within subcortical and prefrontal cortical regions to emotionally salient material in patients with BP and MDD using functional magnetic resonance imaging. METHODS We measured neural responses to mild and… CONTINUE READING
    510 Citations

    Paper Mentions

    Interventional Clinical Trial
    The proposed 3-week, double-blind, crossover, proof of concept study aims to manipulate neurochemical dysfunctions characteristic of individuals with co-occurring BD and AUD (i.e… Expand
    ConditionsAlcohol Use Disorder, Bipolar Disorder
    InterventionDrug
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