Subcortical and ventral prefrontal cortical neural responses to facial expressions distinguish patients with bipolar disorder and major depression

@article{Lawrence2004SubcorticalAV,
  title={Subcortical and ventral prefrontal cortical neural responses to facial expressions distinguish patients with bipolar disorder and major depression},
  author={Natalia S. Lawrence and Andrew M. Williams and Simon A. Surguladze and Vincent Giampietro and Mary L. Phillips},
  journal={Biological Psychiatry},
  year={2004},
  volume={55},
  pages={578-587}
}
BACKGROUND Bipolar disorder (BD) is characterised by abnormalities in mood and emotional processing, but the neural correlates of these, their relationship to depressive symptoms, and the similarities with deficits in major depressive disorder (MDD) remain unclear. We compared responses within subcortical and prefrontal cortical regions to emotionally salient material in patients with BP and MDD using functional magnetic resonance imaging. METHODS We measured neural responses to mild and… CONTINUE READING

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