Subconductance block of single mechanosensitive ion channels in skeletal muscle fibers by aminoglycoside antibiotics

@article{Winegar1996SubconductanceBO,
  title={Subconductance block of single mechanosensitive ion channels in skeletal muscle fibers by aminoglycoside antibiotics},
  author={Bruce D. Winegar and Christine M. Haws and Jeffry B. Lansman},
  journal={The Journal of General Physiology},
  year={1996},
  volume={107},
  pages={433 - 443}
}
The activity of single mechanosensitive channels was recorded from cell-attached patches on acutely isolated skeletal muscle fibers from the mouse. The experiments were designed to investigate the mechanism of channel block produced by externally applied aminoglycoside antibiotics. Neomycin and other aminoglycosides reduced the amplitude of the single-channel current at negative membrane potentials. The block was concentration-dependent, with a half-maximal concentration of approximately 200… CONTINUE READING

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