Subcloning of ovarian cancer cell lines.

  title={Subcloning of ovarian cancer cell lines.},
  author={Thomas W. Grunt},
  journal={Methods in molecular medicine},
Cellular heterogeneity of malignant tissues is a well-known phenomenon (1). Intralineal/intraclonal diversity may be explained in part by proposing the concept of a hierarchically ordered, differentiating and self-renewing stem cell system for transformed cell populations (2). However, in many solid tumors, the stem cells are not easily accessible to… CONTINUE READING